Scientists have been searching for more evidence with regard to pathogenesis and pathophysiology of depression and the resultant neurobiological effects thereof. But the elucidation of the underlying pathophysiology of this condition continues to be elusive. Some theories claim that depression is linked to a dysfunction of the dopaminergic and GABA-ergic system. Others assert that it is associated with a deficit of norepinephrine and serotonin exacerbated by an alteration in the expression of neuropeptides. Yet another theory claims that the overdrive of the hypothalamic-pituitary adrenal system is another risk factor for depression. Chances are that a combination of all these factors can certainly intensify the onset of depression. Depression can be draining. It can take away your energy, dampen your hopes for the future and your drive. It even cripples the desire to do what is needed to feel better. Scientists tell us that some of the symptoms of depression include agitation, significant low sex drive, being irritable, having digestive disorders, experiencing headaches, being fatigued, having feelings of guilty and helplessness as well as insomnia. But there are also times when depressed people might want to sleep all the time.
Although the word ‘depression’ does not appear in the Bible except in the New Living Translation, there are many people who manifested depressive symptoms in the Bible such as Elijah, Hannah, King Saul, John the Baptist, Jeremiah, Job and many others. God does not get upset, nor does He punish us just because we experience discouragement and depression. These disorders are often triggered by events beyond our control such as the death of a loved one, divorce or loss of job. Living in a fallen, sinful world means that we will experience the tragic dimensions of life from time to time until the Lord comes to take us home. The joy of our salvation is in the confident assurance of God’s manward abundant mercies and in the realization that He responds to our hurts as a loving Father. The Bible says in Psalm 34:18 that the LORD is close to the brokenhearted and saves those who are crushed in spirit. It also says “And I will pray the Father, and he shall give you another Comforter, that he may abide with you forever,” (John 14:16). Furthermore, knowing that Jesus was a man of sorrows and acquainted with grief (Isaiah 53: 3) means that He is not a stranger to our suffering, and because He has already been there and has overcome, we also can overcome through Him. This is our hope and our strength through it all.

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