Pharmacogenomics or personalized medicine is based on the concept of using an individual’s genetic profile to determine the best treatment regimen for them. This is facilitated by a prediction of the benefits that individual is likely to obtain from that particular regimen. This prediction takes into account the potential side effects of the treatment as well. Conventional drugs are tested on large population groups from which the average response is reported and recorded. Personalized medicine recognizes that there are no two patients who are alike in every respect. Researchers use the individual’s genomic information to monitor how that individual responds to the drug being studied. In cases where a gene variant might be associated with a particular drug response, it is imperative to make clinical decisions based on that genetic variation. Sometimes, this can require adjustment of the dosage or it might even require choosing alternative therapy altogether. Gene variants that affect a person’s response to a particular drug are assessed in the same manner as gene variants associated with a predisposition to certain types of diseases. Scientists identify the genetic loci that is associated with the response to the drug in question. In such cases they focus on two critical determinants: First, the amount of the drug or the dosage needed to reach its target in the body of the individual and, secondly, how well the cells that are targeted respond to the therapy; particularly heart and brain cells. Scientists call these two determinants pharmacokinetics and pharmacodynamics. Both of them are critical in the field of pharmacogenomics. Pharmacokinetics incorporates four processes known as absorption, distribution, metabolism, and excretion (ADME) of the drug. Pharmacodynamics is the molecular effect of the drug or medication on its target such as a cell surface or an ion channel.
Similarly, God’s calling is personalized; tailor-made to suite our spiritual genetics and to prepare us for the type of service which only we can do. His calling is not only redemptive, it also equips us with special skills needed for that particular service. Sometimes the call may require service in specific communities. No two calls are identical. God’s call may come like a clap of thunder as was the case with the apostle Paul. God can also call people even before they are conceived in their mother’s womb (Jeremiah 1:5). Some people are called centuries before they come into existence. For example, King Josiah was called and named over 300 years before he was born, specifically to bring a stupendous revival to the nation of Israel (1 Kings 13:2). Cyrus the great emperor of Persia was also called and named by God 150 years before he was born, to set in motion the re-building of Jerusalem and to expedite the return of the Jewish exiles from Babylon to their homeland: “I am God…and there is none else…I foretell the end from the beginning (Isa.46: 9,10). There are also times when the call can be a gradual wooing toward a certain direction. For instance, Mother Theresa began to hear the call long before she went to Calcutta to heal and restore dignity to lepers, orphans, AIDS patients, and the poor of India. Henry Martyn was called to the task of translating the New Testament into Hindi and Persian. He also revised an Arabic translation of the New Testament. Martyn accomplished all this in only six years before he died at the age of 31. The calling continues in our day for the need for service is unceasing: “The harvest truly is plenteous, but the laborers are few…” (Matthew 9:37). For more information check out: http://youtu.be/MWkIVDKfh9w